Which laboratory result indicates nephrotoxicity due to cyclosporine?

The identification of nephrotoxicity due to cyclosporine is commonly indicated by an increase in serum creatinine levels. In healthy individuals, creatinine levels typically range from approximately 0.6 to 1.2 mg/dL, depending on muscle mass and other factors. Elevated creatinine levels, such as 2.1 mg/dL, suggest that the kidneys are not effectively filtering waste products from the blood, which is a sign of renal impairment or damage.

Cyclosporine, an immunosuppressant used primarily in organ transplantation, is known to have nephrotoxic effects, which can lead to acute kidney injury. Monitoring renal function, particularly serum creatinine, is crucial when patients are on cyclosporine therapy. A rise in creatinine levels is a clear indicator of potential nephrotoxicity, as it reflects a reduction in the kidney's ability to excrete waste.

While BUN (blood urea nitrogen) levels can also signify kidney function impairment, they are not as specific as creatinine levels for assessing acute changes in kidney function or for detecting nephrotoxicity associated with cyclosporine. Therefore, the appropriate indication of nephrotoxicity in this scenario is the elevated creatinine level of